In multiple myeloma, malignant cells are derived from which lineage?

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Prepare for the Immunology Test in Clinical Laboratory Science. Study with flashcards and multiple-choice questions, each with hints and explanations. Ensure success on your exam!

Multiple Choice

In multiple myeloma, malignant cells are derived from which lineage?

Explanation:
Malignant cells in this disease are mature plasma cells, the antibody-secreting end stage of the B lymphocyte lineage. Plasma cells originate from B cells that have been activated and differentiated; in multiple myeloma, a single clone of these plasma cells expands in the bone marrow and produces a monoclonal immunoglobulin. T lymphocytes and monocytes come from different lineages and do not become plasma cells, so they are not the source of the malignant cells in this condition.

Malignant cells in this disease are mature plasma cells, the antibody-secreting end stage of the B lymphocyte lineage. Plasma cells originate from B cells that have been activated and differentiated; in multiple myeloma, a single clone of these plasma cells expands in the bone marrow and produces a monoclonal immunoglobulin. T lymphocytes and monocytes come from different lineages and do not become plasma cells, so they are not the source of the malignant cells in this condition.

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